How to Write a Systematic Review: A Step-by-Step Guide | The Neuron

How to Write a Systematic Review: A Step-by-Step Guide

Learn how to write a systematic review with our step-by-step guide. Includes ChatGPT prompt.

Written By
Grant Harvey
Grant Harvey
Apr 17, 2024
6 minute read

If you're in the research field, there's a good chance you'll need to write a systematic review at some point in your career. However, if you're new to the process, you may be wondering where to begin. In this article, we'll take a comprehensive look at what a systematic review is and how to write one step-by-step.

Understanding Systematic Reviews

Before we dive into the nitty-gritty of writing a systematic review, it's essential to understand what they are and why they matter.

Systematic reviews are a type of research study that involves collecting and analyzing all available evidence related to a particular research question. These reviews are structured and transparent and follow pre-determined inclusion and exclusion criteria to minimize bias and ensure that the evidence is current, relevant, and reliable.

Systematic reviews are an important tool in evidence-based research and are used to inform clinical decision-making, health policy, and future research. By synthesizing all available evidence related to a particular topic, systematic reviews provide a comprehensive overview of the current research landscape, help identify gaps in knowledge, and inform future research.

What is a Systematic Review?

A systematic review is a comprehensive study that pulls together all available evidence related to a particular research question. This type of review involves a rigorous and transparent process that includes a comprehensive search of the literature, a critical appraisal of the quality of the evidence, and a synthesis of the findings.

Systematic reviews are often used to answer complex research questions or to provide a summary of the current state of knowledge on a particular topic. These reviews can be used to inform clinical practice, health policy, and future research.

Importance of Systematic Reviews in Research

Systematic reviews are a critical component of evidence-based research and are used to inform clinical decision-making, health policy, and future research. By synthesizing all available evidence related to a particular topic, systematic reviews provide a comprehensive overview of the current research landscape, help identify gaps in knowledge, and inform future research.

Systematic reviews are particularly important in fields such as medicine, where decisions about patient care are often based on the best available evidence. By providing a comprehensive and unbiased summary of the available evidence, systematic reviews can help clinicians make informed decisions about patient care.

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Differences Between Systematic Reviews and Other Review Types

It's essential to understand the differences between systematic reviews and other types of reviews to determine which approach is most appropriate for your research.

A scoping review is a type of review that aims to map the available evidence on a particular topic, identify gaps in knowledge, and highlight areas for future research. Scoping reviews are often used to provide an overview of the literature on a particular topic and can help researchers identify areas where further research is needed.

A narrative review is a type of review that aims to provide an overview of the literature related to a particular topic. These reviews are often subjective and may include personal opinions. Narrative reviews are useful for providing a broad overview of a topic, but they may not be as rigorous or transparent as systematic reviews.

In contrast, a systematic review follows a structured and transparent process and adheres to pre-determined inclusion and exclusion criteria to minimize bias and ensure that the evidence is current, relevant, and reliable. Systematic reviews are considered the gold standard in evidence-based research and are often used to inform clinical practice and health policy.

Preparing for Your Systematic Review

Now that we've covered the basics of what a systematic review is let's dive into how to prepare for writing one.

Defining Your Research Question

The first step in writing a systematic review is to define your research question. Your research question should be clear, focused, and answerable through the available literature.

Some tips for formulating your research question include:

  • Be specific and clear
  • Use appropriate search terms
  • Consider the scope of your review (e.g., what studies are included)
  • Consider the purpose of your review (e.g., is a systematic review necessary, or would a scoping review suffice?)
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Developing a Protocol

A protocol is a well-defined plan that outlines your systematic review's objectives, methods, and eligibility criteria. Having a protocol in place before beginning your review helps ensure that the process is transparent, systematic, and reproducible.

Your review protocol should outline the following:

  • Research question(s)
  • Inclusion and exclusion criteria
  • Search strategy
  • Data extraction and synthesis methods

Assembling Your Review Team

Systematic reviews are a significant undertaking that can take months or even years to complete. As such, it's crucial to assemble a reliable review team to ensure that the process is efficient, transparent, and thorough.

Your review team should include:

  • Content experts
  • Methodologists (e.g., statisticians, information specialists)
  • Reviewers (who will conduct the review)
  • Project manager/leader

Now that you have your research question and review protocol in place let's move on to conducting a comprehensive literature search.

Identifying Relevant Databases and Resources

To conduct a comprehensive literature search, you must identify relevant databases and resources. These may include:

  • PubMed
  • Google Scholar
  • EMBASE
  • The Cochrane Library

You should also consider searching for grey literature (i.e., unpublished studies or studies that appear in conference proceedings).

Developing a Search Strategy

Once you've identified your relevant databases and resources, the next step is to develop a search strategy. Your search strategy should be designed to retrieve all relevant studies while minimizing irrelevant studies included in your review.

Your search strategy should include:

  • Search terms (including synonyms and related terms)
  • Search filters (e.g., language, study type)
  • Boolean operators (e.g., AND, OR)
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Managing and Organizing Your Search Results

Conducting a comprehensive literature search can generate hundreds or even thousands of search results. Therefore, it's crucial to manage and organize your search results efficiently.

You can use reference management software such as EndNote or Mendeley to manage your search results. You should also create a screening form to record key information about each study.

Selecting and Screening Studies for Inclusion

Now that you have your search results, it's time to start selecting and screening studies for inclusion in your review.

Establishing Inclusion and Exclusion Criteria

Before beginning the screening process, it's important to establish inclusion and exclusion criteria. These criteria should be based on your research question and review protocol and should be transparent and reproducible.

Screening Titles and Abstracts

Screening titles and abstracts is the first step in the inclusion/exclusion process. You should screen each title and abstract to determine whether the study meets your pre-determined inclusion/exclusion criteria.

Assessing Full-Text Articles

Once you've screened the titles and abstracts, you'll need to assess the full-text articles of studies that meet your inclusion criteria.

You should extract data on study design, population, intervention/exposure, outcomes, and study quality. You can use data extraction forms to standardize this process.

Assessing study quality is also an important aspect of the review process. There are several tools available for assessing study quality, including the Cochrane Risk of Bias Tool and the Joanna Briggs Institute Critical Appraisal Checklist.

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ChatGPT Prompt for Writing a Systematic Review

Use the following prompt in an AI chatbot.

Below each prompt, be sure to provide additional details about your situation. These could be scratch notes, what you'd like to say or anything else that guides the AI model to write a certain way.

ChatGPT Prompt

Please compose a comprehensive and methodical analysis of existing literature on a specific topic or research question, utilizing a systematic and rigorous approach to identify, evaluate, and synthesize relevant studies. This review should aim to provide a thorough and unbiased summary of the current state of knowledge on the topic, highlighting any gaps or inconsistencies in the literature and offering insights for future research.

[ADD ADDITIONAL CONTEXT. CAN USE BULLET POINTS.]

Conclusion

Writing a systematic review is a rigorous and time-consuming process, but it's an essential component of evidence-based research. By following the steps outlined in this guide, you can ensure that your review is transparent, systematic, and reproducible.

Remember to define your research question, develop a protocol, assemble a reliable review team, conduct a comprehensive literature search, and select and screen studies for inclusion/exclusion.

Grant Harvey

Grant Harvey is the Lead Writer of The Neuron, where he continues to lead the publication's daily coverage of AI news, tools, and trends.

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